$B:P;~5-!'D97n$N9`(B

$B0lF|(B

$BEvD>L@!#!E!E?2$k2K$bL5$/$=$N8eGc$$J*$J$I!#(B

$BM?F$O%H%l%C%-%s%0$K9T$C$?5"$j$K=BBZ$K4,$-9~$^$l$FCY9o$9$k!#J9$1$P(B($BEE$B$*NAM}$O$H$F$b$*$$$7$/?)$Y$i$l$F!"3Z$7$$$R$H$H$-$@$C$?!#$7$+$7!"?F$H;R!\$=$NG[6v

$B;0F|(B

$BD+$+$i5_5^30Mh!"8a8e$OIBEo$G!"Lk$O30MhEvD>8&=$!#(B
$B30MhEvD>8&=$$O$^$:$OGq$^$i$:$KA0H>ItJ,$N$_$N8&=$!#K\D>$N(BDr$B$,8e$m$K95$($F!"45 $B5_5^30Mh$G?GNE$NMM;R$r%A%'%C%/$5$l$J$/$J$C$F$$$k$+$i!"2~$a$F$3$N;~4|$K%A%'%C%/$5$l$k$H!"$$$m$$$m%"%I%P%$%9$,Lc$($F!"$=$&$$$&0UL#$G$bM-1W$JLk$@$C$?!#(B

$B;MF|(B

$B:#D+$NJY6/2q$N$*BjL\$O(BNew England Jornal of Medicine$B;o$N(BM.G.H.$B$N%1!<%9%+%s%U%!%l%s%9$N1QJ8>6FI!#>INc%W%l%<%s%F!<%7%g%s$r$o$?$7$,C4Ev!"$H$$$&$3$H$G!"L2$$L\$r$3$9$C$F=P$+$1$F$$$/!#(B
$B7k9=D9$$IBNr$r$^$H$a$"$2$?$N$G!":rF|$^$G$,7k9=Hh$l$?!#5U$K$3$NF|$OH/I=$9$k$@$1$J$N$G5$3Z$G$O$"$C$?!#(B

$B8^F|(B

$B$=$m$=$m=[4D4o8&=$$b=*$o$j!#45

$B$=$s$G$b$C$FK\F|EvD>!#(B
$BLk3FIBEo$r2s?G$7$F2s$j!"MWCm0U45 $B=P?HCO6a$/$G0e

$BO;F|(B

$B=[4D4o8&=$:G=*F|!#

$B8a8e$+$i0lG/H>$NAm3g9g=I!#9T$-$NEE $B$H$K$+$/!VL5A,0{?)NsEA!W$,5$$KF~$C$?!#?\F#>=Jf$H0KN$Ln2CF`$NAT@d$JBg?)$$%P%H%k!#(B"$BE4?MDj?)(B"$B$N$9$5$^$8$5$O$o$?$7$J$i$-$C$HE4?M%i!<%a%s$r?)$Y$k$N$,@:$$$C$Q$$$@$m$&$H;W$o$;$k$b$N$@$7!"$=$l$r?)$$@Z$k$^$G$N7lAv$k$h$&$J0UCO$ND%$j9g$$$,%i%$%V46$?$C$W$j$KEA$o$C$F$/$k!#(B
$B$=$NMbF|$N%(%T%=!<%I$N$"$C$?$+$5$b5$;}$A$h$$!#$=$N#4$,3Z$7$_$J:nIJ!#(B

$B$J$*!"=tHL$N;v>p$K$h$j$7$P$i$/99?7$,ES@d$($^$9!#$"$7$+$i$:$4N;>5$/$@$5$$!#(B

$BFs==;MF|(B

$B=tHL$N;v>p$N4V$K2?$r$7$F$$$?$+$O8eF|8x3+$9$kM=Dj!#(B

$B$s$G!"5W$7$V$j$K=P6P!#K\F|$h$j>C2=4o2J8&=$!#(B
$B$7$+$7!"=iF|$OF~1!45F|!"=qN`=q$-$J$I$7$F2a$4$9!#(B
$B8a8e$+$i$O=i$N0lHL30Mh!#NY$KAjCLLr$N@h@8$O$$$k$b$N$N!"0l?M$G?GNE$r$9$k$3$H$H$J$k!#%+%<$J$I$J$i$$$$$N$@$1$l$I!"!V$*$J$+$,D%$C$F6l$7$$!W!V:rF|7l05$,9b$/$F5$J,$,0-$+$C$?(B($B:#F|$O2?$H$b$J$$(B)$B!W$J$I$O!E!E%^%K%e%"%k$N$J$$@$3&$G!"$J$+$J$+LLE]!#(B

$BFs==8^F|(B

$B$R$H$j$a$N45 $B$G$b!"$3$N45

$B;0==F|(B

$B%*%K$N$h!<$KK;$7$$F|!9$f$($K99?7$b$^$^$J$i$:!#5-21$NHt$S$,@8$8$F$/$k!#(B

$B$3$NF|$OEvD>L@$1!#(B
$B0l:rF|F~$C$?%"%k%3!<%k0MB8$N45I>u$rDh$7$F$-$F$$$k!#LQA[$b0U<1>c32$b@8$8$F$-$F$$$F!"E57?E*$J>I>u!#K=$l=P$7$F@);_$,8z$+$J$$!#(B
$B$*c32$rDh$7$F$-$F$$$k45 $B%"%k%3!<%k$KBP$7$FA4BN$KF|K\?M$OuBV$@$H;W$&!#(B
$BB>$K$3$NF|Ig91j!#$3$l$b%"%k%3!<%k@-$N$b$N$,$"$C$FL?$K$b$+$+$o$k!#>C2=4o2J$K$$$k$H!"$*$B!!(B


Written by Genesis
$B46A[Ey$O!"(B$B7G<(HD(B$B$+([email protected]$B$^$G!#%j%s%/$O$4<+M3$K!#(B

$BF|5-$N%H%C%W$X(B
$B%[!<%`%Z!<%8$X(B